Year: 2018

SUPPLEMENTARY PROSPECTUS

CHANGE IN SUBSTANTIAL HOLDING

CHANGE OF DIRECTOR’S INTEREST NOTICE

REVISED PROSPECTUS TIMETABLE

CHANGE OF DIRECTOR’S INTEREST NOTICE

2017 R&D INCENTIVE REFUND RECEIVED

LETTER TO SHAREHOLDER

LETTER TO OPTIONHOLDER

APPENDIX 3B

PROSPECTUS FOR NON-RENOUNCEABLE PRO-RATA RIGHTS ISSUE